Big Ten and biggest college football game picks and predictions for Week 5

Our writers take turns picking all of the Big Ten and the biggest college football games against the spread and straight up for Week 5 of the season.

It's tradition now. Every year (and every week of the season) we have a little friendly competition among our writers for world domination when it comes to picking the Big Ten football games and some of the bigger college football contests throughout the season once conference play gets into full swing.

Though we never really know, Ohio StateOregon, and Penn State, are getting a lot of national notoriety and were picked by media members to be the three teams contending for league superiority. You can't count out Michigan despite the loss to Oklahoma, and teams like USC, WashingtonIowa, Illinois, and Nebraska hope to also be upstarts and surprise folks.

So, just how will Week 5 play out in the Big Ten? Our writers take turns picking all the games in the Big Ten straight up and against the spread for your wagering and reading consumption — do with it as you wish.

As a reminder, if there’s an asterisk next to the pick, that means the team will win, but not cover. If there is a tie, rather than have a cage match or old-fashioned duel, we’ll settle it with less violence and go with the tried, yet true, coin flip, where George Washington has the say.

EXAMPLE: If Ohio State is favored -3.5 over Michigan:

If you think Ohio State will win outright and cover: OSU

If you think Ohio State will win, but NOT cover: OSU*

If you think Ohio State will lose: Michigan

Here are our expert picks for Week 2 as we see if what we saw during opening weekend holds true this week. But first, here are the standings so far from our writers.

Ohio State odds for Week 5

Standings so far

Follow Phil Harrison: 55-4 SU, 35-24 ATS

Follow MarkRussell: 52-7 SU, 32-27 ATS

Follow Yesh Ginsburg: 49-10 SU, 37-22 ATS

Follow Griffin Dreifeldt: 55-4 SU, 38-21 ATS

CONSENSUS PICK53-6 SU, 39-20 ATS

USC at Illinois

Sep 6, 2025; Los Angeles, California, USA; USC Trojans running back Waymond Jordan (2) Georgia Southern Eagles defensive back Ayden Jackson (5) and runs into the end zone for a touchdown during the second half at the Los Angeles Memorial Coliseum. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images

Saturday, Sept. 27

Noon ET | Fox (Stream fuboTV (watch here))

Betting Line | USC -6.5

The Picks:

Phil Harrison (@PhilHarrisonBW) | USC

Mark Russell (@MarkRussell1975) | USC

Griffin Dreifaldt (@griffin_drei) | USC

Yesh Ginsburg (@yesh222) | USC

CONSENSUS PICK | USC

Rutgers at Minnesota

Aug 28, 2025; Minneapolis, Minnesota, USA; Minnesota Golden Gophers wide receiver Jalen Smith (8) catches a pass against the Buffalo Bulls during the second half of the game at Huntington Bank Stadium. Mandatory Credit: Matt Krohn-Imagn Images

Saturday, Sept. 27

Noon ET | Big Ten Network (Stream fuboTV (watch here))

Betting Line | Minnesota -5.5

The Picks:

Phil Harrison (@PhilHarrisonBW) | Minnesota*

Mark Russell (@MarkRussell1975) | Minnesota

Griffin Dreifaldt (@griffin_drei) | Rutgers

Yesh Ginsburg (@yesh222) | Rutgers

CONSENSUS PICK | Rutgers

Ohio State at Washington

Ohio State Buckeyes wide receiver Jeremiah Smith (4) catches a 47-yard touchdown pass in front of Ohio Bobcats cornerback Michael Mack II (9) during the second half of the NCAA football game at Ohio Stadium on Sept. 13, 2025. Ohio State won 37-9.

Saturday, Sept. 27

3:30 p.m. ET | CBS/Paramount+ (Stream fuboTV (watch here))

Betting Line | Ohio State -8

The Picks:

Phil Harrison (@PhilHarrisonBW) | Ohio State*

Mark Russell (@MarkRussell1975) | Ohio State

Griffin Dreifaldt (@griffin_drei) | Ohio State*

Yesh Ginsburg (@yesh222) | Ohio State

CONSENSUS PICK: Ohio State

Indiana at Iowa

Aug 31, 2024; Iowa City, Iowa, USA; Iowa Hawkeyes tight end Luke Lachey (85) looks for yards after catch against the Illinois State Redbirds during the second quarter at Kinnick Stadium. Mandatory Credit: Jeffrey Becker-USA TODAY Sports

Saturday, Sept. 27

3:30 p.m. ET | Peacock

Betting Line | Indiana -7.5

The Picks:

Phil Harrison (@PhilHarrisonBW) | Indiana

Mark Russell (@MarkRussell1975) | Indiana

Griffin Dreifaldt (@griffin_drei) | Indiana

Yesh Ginsburg (@yesh222) | Indiana

CONSENSUS PICK | Indiana

UCLA at Northwestern

Aug 30, 2025; New Orleans, Louisiana, USA; Northwestern Wildcats quarterback Preston Stone (8) passes against Tulane Green Wave during the second half at Yulman Stadium. Mandatory Credit: Stephen Lew-Imagn Images

Saturday, Sept. 27

3:30 p.m. ET | Big Ten Network (Stream fuboTV (watch here))

Betting Line | Northwestern -6.5

The Picks:

Phil Harrison (@PhilHarrisonBW) | Northwestern

Mark Russell (@MarkRussell1975) | Northwestern*

Griffin Dreifaldt (@griffin_drei) | Northwestern

Yesh Ginsburg (@yesh222) | Northwestern

CONSENSUS PICK | Northwestern

Oregon at Penn State

Sep 13, 2025; University Park, Pennsylvania, USA; Penn State Nittany Lions wide receiver Devonte Ross (5) runs with the ball during the first quarter against the Villanova Wildcats at Beaver Stadium. Mandatory Credit: Matthew O'Haren-Imagn Images

Saturday, Sept. 27

7:30 p.m. ET | NBC/Peacock (Stream fuboTV (watch here))

Betting Line | Penn State -3.5

The Picks:

Phil Harrison (@PhilHarrisonBW) | Penn State

Mark Russell (@MarkRussell1975) | Oregon

Griffin Dreifaldt (@griffin_drei) | Oregon

Yesh Ginsburg (@yesh222) | Oregon

CONSENSUS PICK | Oregon

Next ... Five biggest national games

Notre Dame at Arkansas

Notre Dame head coach Marcus Freeman celebrates a touchdown scored during the first round of the College Football Playoff between Notre Dame and Indiana University at Notre Dame Stadium on Friday, Dec. 20, 2024, in South Bend.

Saturday, Sept. 27

Noon ET | ABC (Stream fuboTV (watch here))

Betting Line | Notre Dame -4.5

The Picks:

Phil Harrison (@PhilHarrisonBW) | Notre Dame

Mark Russell (@MarkRussell1975) | Notre Dame

Griffin Dreifaldt (@griffin_drei) | Notre Dame*

Yesh Ginsburg (@yesh222) | Notre Dame

CONSENSUS PICK | Notre Dame

LSU at Ole Miss

Sep 6, 2025; Seattle, Washington, USA; Washington Huskies running back Jonah Coleman (1) rushes for a touchdown against the UC Davis Aggies during the first quarter at Husky Stadium. Mandatory Credit: Joe Nicholson-Imagn Images

Saturday, Sept. 27

3:30 p.m. ET | ABC (Stream fuboTV (watch here))

Betting Line | Ole Miss -1.5

The Picks:

Phil Harrison (@PhilHarrisonBW) | Ole Miss

Mark Russell (@MarkRussell1975) | LSU

Griffin Dreifaldt (@griffin_drei) | Ole Miss

Yesh Ginsburg (@yesh222) | LSU

CONSENSUS PICK | Ole Miss

Auburn at Texas A&M

Nov 7, 2020; Columbia, South Carolina, USA; Texas A&M Aggies tight end Jalen Wydermyer (85) and Texas A&M Aggies quarterback Kellen Mond (11) celebrate a Mond touchdown in the third quarter at Williams-Brice Stadium. Mandatory Credit: Jeff Blake-USA TODAY Sports

Saturday, Sept. 27

3:30 p.m. ET | ESPN (Stream fuboTV (watch here))

Betting Line | Texas A&M -6.5

The Picks:

Phil Harrison (@PhilHarrisonBW) | Texas A&M

Mark Russell (@MarkRussell1975) | Texas A&M

Griffin Dreifaldt (@griffin_drei) | Texas A&M*

Yesh Ginsburg (@yesh222) | Texas A&M

CONSENSUS PICK | Texas A&M

Tennessee at Mississippi State

Dec 5, 2020; Knoxville, Tennessee, USA; Tennessee Volunteers mascot Smokey during the second half against the Florida Gators at Neyland Stadium. Mandatory Credit: Randy Sartin-USA TODAY Sports

Saturday, Sept. 27

4:15 p.m. ET | SEC Network (Stream fuboTV (watch here))

Betting Line | Tennessee -8.5

The Picks:

Phil Harrison (@PhilHarrisonBW) | Tennessee*

Mark Russell (@MarkRussell1975) | Tennessee

Griffin Dreifaldt (@griffin_drei) | Tennessee

Yesh Ginsburg (@yesh222) | Tennessee

CONSENSUS PICK | Tennessee

Alabama at Georgia

Sep 24, 2022; Corvallis, Oregon, USA; USC Trojans quarterback Caleb Williams (13) runs against Oregon State Beavers defensive back Rejzohn Wright (2) at Reser Stadium. Mandatory Credit: Jaime Valdez-USA TODAY Sports

Saturday, Sept. 27

7:30 p.m. ET | ABC (Stream fuboTV (watch here))

Betting Line | Georgia -3

The Picks:

Phil Harrison (@PhilHarrisonBW) | Georgia

Mark Russell (@MarkRussell1975) | Georgia

Griffin Dreifaldt (@griffin_drei) | Alabama

Yesh Ginsburg (@yesh222) | Georgia

CONSENSUS PICK | Georgia

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This article originally appeared on Buckeyes Wire: Big Ten and big game college football picks and predictions for Week 5

Category: General Sports