NFL Expert Picks for Week 4 of 2025

Now that was a surprising week to come off. We had the Browns beating the Packers, the Panthers shutting out the Falcons, and Caleb Williams putting it all together for a big win against Dallas. We’ve learned through the first month of the season that preconceived notions are out the window, and separating the good from the bad is still damn-near impossible in the NFL with offenses really struggling to find their footing league-wide.

We roll into Week 4 with a few really interesting statement games on the slate. This opens up on Thursday Night Football with Seahawks vs. Cardinals. Both teams are battling in the NFC West with the division-leading 49ers, who are finding themselves mired in injury woes, but still managing to keep up. Seattle is rolling right now and look like a very solid team, while Arizona took a big step backwards in Week 3 losing to a Mac Jones-led Niners team without George Kittle and several other big-name players.

Two other fascinating games to circle will be Colts vs. Rams, where we’ll get a better sense for whether this Indianapolis team with Daniel Jones under center is actually for real, and then Ravens vs. Chiefs — two teams assumed to be the best in the AFC, but both of whom have had struggles to start the season.

Here’s our panel’s picks for this week in the NFL.