Buffalo Bills vs. New Orleans Saints: 3 key matchups to watch in Week 4

The Buffalo Bills will host the New Orleans Saints at Highmark Stadium in Week 4.

For this cross-conference battle between Sean McDermott's Bills (3-0) and Kellen Moore's Saints (0-3), it will be the games, within the game, that will make all the difference.

Here are Bills Wire's three key matchups to watch during Sunday’s Bills-Saints contest:

Bills CB Christian Benford vs. Saints WR Chris Olave

The Bills did not get a great outing from Benford in Week 3 against the Dolphins. Regardless, he is still their No. 1 cornerback and Olave is the Saints' top wide receiver.

Benford will look for a bounce-back effort against New Orleans.

Bills LB Terrel Bernard vs. Saints RB Alvin Kamara

Bernard is not the only one who will factor into shutting down the run game. However, with the struggles the Bills have had against top rushers such as Derrick Henry, Bernard will lead the line in terms of stopping Kamara.

Bills OL Spencer Brown vs. Saints EDGE Carl Granderson

Granderson is a leading the Saints in sacks in 2025 with 3.5 through three games. Cameron Jordan is also a factor for New Orleans off the edge, but Granderson is the clear player to be aware of in terms of protecting quarterback Josh Allen.

This article originally appeared on Bills Wire: Buffalo Bills vs New Orleans Saints: 3 key matchups to watch in Week 4