49ers QB Brock Purdy ruled out of Thursday night matchup with Rams due to toe injury

Jauan Jennings, Ricky Pearsall and Jordan Watkins were all ruled out due to various injuries, too.

SANTA CLARA, CALIFORNIA - SEPTEMBER 28: Brock Purdy #13 of the San Francisco 49ers warms up prior to the game against the Jacksonville Jaguars at Levi's Stadium on September 28, 2025 in Santa Clara, California. (Photo by Brooke Sutton/Getty Images)
SANTA CLARA, CALIFORNIA - SEPTEMBER 28: Brock Purdy #13 of the San Francisco 49ers warms up prior to the game against the Jacksonville Jaguars at Levi's Stadium on September 28, 2025 in Santa Clara, California. (Photo by Brooke Sutton/Getty Images)
Brooke Sutton via Getty Images

Brock Purdy won’t be able to take the field on Thursday night after all.

The San Francisco 49ers ruled Purdy out of their matchup with the Los Angeles Rams officially on Wednesday afternoon due to a toe injury. He was hopeful this week that he could return in time for the contest, but he has not yet practiced this week due to toe soreness.

Purdy was one of several offensive stars that was ruled out of the contest on Wednesday. Wide receivers Jauan Jennings, Ricky Pearsall and Jordan Watkins were all ruled out due to various injuries, too.

With Purdy out, Mac Jones will get the start on Thursday night at SoFi Stadium. Jones, who was dealing with a sprained knee himself, has been cleared to practice normally.

This post will be updated with more information shortly.

Category: General Sports