Our Week 5 Thursday Night Football picks are in. Who will win as the 49ers face the Rams?
The NFL calendar is on to Week 5, with the San Francisco 49ers face the Los Angeles Rams for the Thursday Night Football kickoff to the week. Both teams enter the game with a 3-1 record, tied for the lead at the top of the NFC West. Tonight’s game also marks the second-straight NFC West rivalry game on Thursday night, following last week’s meeting between the Seattle Seahawks and Arizona Cardinals.
The NFC West is tight early this year, with the Rams, 49ers, and Seahawks all holding identical 3-1 records while the Cardinals are just a game back at 2-2. Could tonight’s game spark a run from either the 49ers or the Rams?
Throughout the season, our contributors predict the winner for each game on the schedule. We primarily focus on the outright winner of each game from Week 1 through the Super Bowl, but we can also pick against the spread. You can check out our picks below in the widget provided to us by Tallysight.
Week 5 – Thursday Night Football
San Francisco 49ers (3-1) at (3-1) Los Angeles Rams
8:15 p.m. Eastern, Thursday, Oct. 2
Spread: Rams -7.5
Point Total: 44.5
Moneyline: 49ers +350 | Rams -460
Odds by FanDuel sportsbook.
Week 4 Results
Sumeet Jena (11-4-1)
Kevin Nogle (10-5-1)
Marek Brave (10-5-1)
James McKinney (9-6-1)
2025 Standings
(Through Week 4)
Kevin Nogle (44-19-1)
Sumeet Jena (44-19-1)
James McKinney (42-21-1)
Marek Brave (41-22-1)
Week 5 – Thursday Night Football picks
Category: General Sports
