Get the opening NFL Week 7 odds with point spreads, Over/Unders, and football moneylines for every matchup starting on Oct. 16, 2025.
NFL Week 7 opens with a Thursday Night Football clash between AFC North rivals, the Pittsburgh Steelers and Cincinnati Bengals.
We've got another international contest on tap for Sunday morning, when the Los Angeles Rams and Jacksonville Jaguars face off at London's Wembley Stadium.
The biggest game on Sunday's slate is arguably the Philadelphia Eagles looking to avenge their upset loss to the New York Giants by taking on the Minnesota Vikings as road favorites.
The day wraps with the Atlanta Falcons and San Francisco 49ers on Sunday Night Football before giving way to another Monday doubleheader: Tampa Bay Buccaneers at Detroit Lions and Houston Texans at Seattle Seahawks.
Let's take a look at NFL Week 7 odds.
NFL odds Week 7
| Matchup | Spread | Moneyline | Over/Under |
|---|---|---|---|
 Steelersvs  Bengals | Bengals +5.5 | Steelers -265 Bengals +215 | 42.5 |
 Ramsvs  Jaguars | Jaguars +3 | Rams -166 Jaguars +140 | 46.5 |
 Patriotsvs  Titans | Titans +6.5 | Patriots -325 Titans +260 | 42.5 |
 Saintsvs  Bears | Bears -5.5 | Saints +210 Bears -258 | 45.5 |
 Dolphinsvs  Browns | Browns -1.5 | Dolphins +110 Browns -130 | 41.5 |
 Panthersvs  Jets | Jets -1.5 | Panthers +100 Jets -120 | 45.5 |
 Eaglesvs  Vikings | Vikings +2.5 | Eagles -135 Vikings +114 | 42.5 |
 Raidersvs  Chiefs | Chiefs -10.5 | Raiders +410 Chiefs -550 | 45.5 |
 Giantsvs  Broncos | Broncos -7 | Giants +300 Broncos -380 | 39.5 |
 Coltsvs  Chargers | Chargers -1.5 | Colts +100 Chargers -120 | 48.5 |
 Commandersvs  Cowboys | Cowboys +2.5 | Commanders -148 Cowboys +124 | 54.5 |
 Packersvs  Cardinals | Cardinals +7 | Packers -360 Cardinals +285 | 43.5 |
 Falconsvs  49ers | 49ers -3.5 | Falcons +145 49ers -175 | 45.5 |
 Buccaneersvs  Lions | Lions -5.5 | Buccaneers +210 Lions -255 | 53.5 |
 Texansvs  Seahawks | Seahawks -3 | Texans +124 Seahawks -148 | 42.5 |
Lines as of 10-12
Steelers vs Bengals odds (Thursday, 8:15 p.m., Prime Video)
Opening line
- Bengals +4.5
- Over/Under 42.5
- View full Steelers vs. Bengals odds and matchup
- Read our Steelers vs. Bengals picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Thursday Night Football odds
Rams vs Jaguars odds (Sunday, 9:30 a.m., NFL Network)
Opening line
- Jaguars +3.5
- Over/Under 47.5
- View full Rams vs. Jaguars odds and matchup
- Read our Rams vs. Jaguars picks and predictions (coming soon)
Opening line analysis coming soon!
Patriots vs Titans odds (Sunday, 1:00 p.m., CBS)
Opening line
- Titans +6.5
- Over/Under 42.5
- View full Patriots vs. Titans odds and matchup
- Read our Patriots vs. Titans picks and predictions (coming soon)
Opening line analysis coming soon!
Covers NFL betting tools
Saints vs Bears odds (Sunday, 1:00 p.m., FOX)
Opening line
- Bears -6.5
- Over/Under 44.5
- View full Saints vs. Bears odds and matchup
- Read our Saints vs. Bears picks and predictions (coming soon)
Opening line analysis coming soon!
Dolphins vs Browns odds (Sunday, 1:00 p.m., CBS)
Opening line
- Browns -2.5
- Over/Under 41.5
- View full Dolphins vs. Browns odds and matchup
- Read our Dolphins vs. Browns picks and predictions (coming soon)
Opening line analysis coming soon!
Panthers vs Jets odds (Sunday, 1:00 p.m., FOX)
Opening line
- Jets -2.5
- Over/Under 43.5
- View full Panthers vs. Jets odds and matchup
- Read our Panthers vs. Jets picks and predictions (coming soon)
Opening line analysis coming soon!
Covers NFL awards analysis
Eagles vs Vikings odds (Sunday, 1:00 p.m., FOX)
Opening line
- Vikings +3
- Over/Under 42.5
- View full Eagles vs. Vikings odds and matchup
- Read our Eagles vs. Vikings picks and predictions (coming soon)
Opening line analysis coming soon!
Raiders vs Chiefs odds (Sunday, 1:00 p.m., CBS)
Opening line
- Chiefs -11.5
- Over/Under 46.5
- View full Raiders vs. Chiefs odds and matchup
- Read our Raiders vs. Chiefs picks and predictions (coming soon)
Opening line analysis coming soon!
Giants vs Broncos odds (Sunday, 4:05 p.m., CBS)
Opening line
- Broncos -8.5
- Over/Under 40.5
- View full Giants vs. Broncos odds and matchup
- Read our Giants vs. Broncos picks and predictions (coming soon)
Opening line analysis coming soon!
More NFL betting analysis
- Aaron Rodgers’ record vs. every NFL team
- Patrick Mahomes’ record vs. every NFL team
- Russell Wilson’s record vs. every NFL team
- Josh Allen’s record vs. every NFL team
- Lamar Jackson’s record vs. every NFL team
Colts vs Chargers odds (Sunday, 4:05 p.m., CBS)
Opening line
- Chargers -1.5
- Over/Under 48.5
- View full Colts vs. Chargers odds and matchup
- Read our Colts vs. Chargers picks and predictions (coming soon)
Opening line analysis coming soon!
Commanders vs Cowboys odds (Sunday, 4:25 p.m., FOX)
Opening line
- Cowboys +2.5
- Over/Under 51.5
- View full Commanders vs. Cowboys odds and matchup
- Read our Commanders vs. Cowboys picks and predictions (coming soon)
Opening line analysis coming soon!
Packers vs Cardinals odds (Sunday, 4:25 p.m., FOX)
Opening line
- Cardinals +4.5
- Over/Under 44.5
- View full Packers vs. Cardinals odds and matchup
- Read our Packers vs. Cardinals picks and predictions (coming soon)
Opening line analysis coming soon!
Falcons vs 49ers odds (Sunday, 8:20 p.m., NBC)
Opening line
- 49ers -4.5
- Over/Under 45.5
- View full Falcons vs. 49ers odds and matchup
- Read our Falcons vs. 49ers picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Sunday Night Football odds
Buccaneers vs Lions odds (Monday, 7:00 p.m., ABC/ESPN)
Opening line
- Lions -5.5
- Over/Under 52.5
- View full Buccaneers vs. Lions odds and matchup
- Read our Buccaneers vs. Lions picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Monday Night Football odds
Texans vs Seahawks odds (Monday, 10:00 p.m., ESPN)
Opening line
- Seahawks -3
- Over/Under 42.5
- View full Texans vs. Seahawks odds and matchup
- Read our Texans vs. Seahawks picks and predictions (coming soon)
Opening line analysis coming soon!
Best NFL bets this week
Looking for our favorite spread, total, and NFL prop bets for this week's action? Check out our best free NFL picks from the Covers staff!
Odds are correct at the time of publishing and are subject to change.
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Category: Football
